International Review of Ophthalmology

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MicroRNAs and age-related macular degeneration

HU Juan, XUE Li-ping   

  1. Department of Ophthalmology, the Fourth Affiliated Hospital of Kunming Medical University, Kunming 650021, China
  • Received:2016-12-28 Online:2017-04-22 Published:2017-04-20
  • Contact: XUE Li-ping，Email: 1039186778@qq.com
  • Supported by:

    The Key Project Initiated by the Scientific Research Fund of the Education Department in Yunnan Province(2015Z076); The Project of Medical Hygiene in Yunna Province(2016NS184)

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Abstract:

MicroRNA (miRNA) refers to a small endogenous non-coding RNA molecule. Its abnormal expression is closely related to the development of age-related macular degeneration (AMD). MiRNA plays an important role in pathogenesis of AMD, including the inflammatory response, oxidative stress injury, amyloid, choroidal neovascularization(CNV) and other lesions development. These findings may provide new possibilities for early diagnosis, treatment and prognosis judgment of AMD. (Int Rev Ophthalmol,  2017,  41:    79-82)